منابع مشابه
Nucleotide analogue inhibitors of purine nucleoside phosphorylase.
The diphosphate of the antiherpetic agent acyclovir [9-[(2-hydroxyethoxy)methyl]guanine] has been shown to inhibit purine nucleoside phosphorylase with unique potency (Tuttle, J. V., and Krenitsky, T. A. (1984) J. Biol. Chem. 259, 4065-4069). A major factor contributing to the superior inhibition by this diphosphate over the corresponding mono- and triphosphates is revealed here. Homologues of ...
متن کاملExtracellular nucleotide and nucleoside signaling in vascular and blood disease.
Nucleotides and nucleosides-such as adenosine triphosphate (ATP) and adenosine-are famous for their intracellular roles as building blocks for the genetic code or cellular energy currencies. In contrast, their function in the extracellular space is different. Here, they are primarily known as signaling molecules via activation of purinergic receptors, classified as P1 receptors for adenosine or...
متن کاملCoordinated Adenine Nucleotide Phosphohydrolysis and Nucleoside Signaling in Posthypoxic Endothelium
Limited oxygen delivery to tissues (hypoxia) is common in a variety of disease states. A number of parallels exist between hypoxia and acute inflammation, including the observation that both influence vascular permeability. As such, we compared the functional influence of activated polymorphonuclear leukocytes (PMN) on normoxic and posthypoxic endothelial cells. Initial studies indicated that a...
متن کاملToward a pharmacogenetic understanding of nucleotide and nucleoside analogue toxicity.
Antiretroviral therapies for HIV-1 infection have become progressively more potent and better tolerated. An important milestone was the 2001 Food and Drug Administration approval of tenofovir di-soproxil fumarate (TDF), a once-daily nucleotide analogue reverse-transcriptase in-hibitor that is available commercially as a single agent (Viread; Gilead Sciences), co-formulated with emtricitabine (T...
متن کاملAntiadenovirus activities of several classes of nucleoside and nucleotide analogues.
The absence of any formally licensed antiadenovirus drugs and the increasing incidence of life-threatening adenovirus infections in immunosuppressed patients warrant the development of effective antiadenovirus compounds. A detailed study was performed on the antiadenovirus activities of several classes of nucleoside and nucleotide analogues in human embryonic lung fibroblast cells. The antiaden...
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ژورنال
عنوان ژورنال: Current Protocols in Nucleic Acid Chemistry
سال: 2000
ISSN: 1934-9270,1934-9289
DOI: 10.1002/0471142700.nca01ds00